Fig. 1.

ALK levels are higher in ALK mutant than wild type NBL cell lines. Higher a ALK mRNA (p < 0.01) b ALK 220 kDa protein (p < 0.01) and c ALK 140 kDa protein (p < 0.01) levels in ALK mutant than WT NBL cell lines. d No significant difference of Y1604 pALK levels between mutant (squares) and wild type (dots) cell lines (p = 0.70). MUT, ALK point mutation; WT, ALK wild type gene, including copy number gains (amplified lines are indicated as dots). Western blots displayed in Supplementary Figure 2 and 3