Skip to main content
. 2011 May 31;34(5):409–417. doi: 10.1007/s13402-011-0048-2

Fig. 4.

Fig. 4

Responsiveness to ALK inhibitor TAE684 is correlated with ALK mRNA and ALK protein levels. a ALK mRNA levels relate to in-vitro sensitivity towards the ALK inhibitor TAE684 (Spearman’s rho r = −0.75, p = 0.01), the black line is a linear fit. ALK mRNA levels in mutated (black squares, Spearman’s rho r = −0.32, p = 0.68) and WT cell lines (black triangles are WT; dots are AMP, spearman’s rho r = −0.14, p = 0.79) independently tend to correlate with ALK inhibitor response. b ALK 220 kDa (black symbols, spearman’s rho r = −0.81, p < 0.01) and 140 kDa (grey symbols, spearman’s rho r = −0.84, p < 0.01) protein levels relate to the in vitro sensitivity towards the ALK inhibitor TAE684. A linear line was fitted (black for 220 kDa protein, grey for 140 kDa protein). ALK 220 kDa protein levels of mutants are displayed by black squares (spearman’s rho r = −0.32, p = 0.68) and WTs by black triangles (WT) and black dots (AMP) (spearman’s rho r = −0.43, p = 0.29). ALK 140 kDa protein levels mutants by grey squares (spearman’s rho r = −0.11, p = 0.90) and WTs by grey triangles (WT) and grey circles (AMP) (spearman’s rho r = −0.71, p = 0.05)