Table 1.
Copy number status of the MYCN and ALK gene, as well as mutation status of the ALK gene in NBL cell lines
| Cell line | NMYC amplified (+/−) | ALK amplified (+/−) | ALK mutated (type of mutation) |
|---|---|---|---|
| AMC106C | + | − | F1174L |
| SK-N-FI | + | − | R1275Q |
| GI-ME-N | − | − | − |
| IMR-32 | + | − | − |
| KCNR | + | − | F1174L |
| LAN-5 | + | − | R1275Q |
| N206 | + | − | F1174L |
| SK-N-AS | − | − | − |
| NGP-C4 | + | − | − |
| NMB | + | + | − |
| SJNB-1 | − | − | − |
| SJNB-6 | + | − | − |
| SJNB-8 | + | − | − |
| SJNB-10 | + | − | − |
| SJNB-12 | − | − | − |
| SK-N-BE | + | + | − |
| SK-N-SH | − | − | F1174L |
| TR-14 | + | + | − |
| UHG-NP | + | + | − |
aAmplification was identified as having =/>5 gene copies; F1174L, p.Phe1174Leu; R1275Q, p.Arg1275Gln