Table 2.
Overview of ALK mutated and wild type NBL cell lines, displaying ALK levels and sensitivity to TAE684
| Cell line | ALK mutation status | ALK mRNAa | ALK (220 kDa)/GAPDH | ALK (140 kDa)/GAPDH | pALK (220 kda)/GAPDH | LC50 TAE684 |
|---|---|---|---|---|---|---|
| SK-N-SH | MUT | 8.7 | 4.4 | 7.0 | 0.9 | 9.4 |
| LAN-5 | MUT | 9.1 | 3.5 | 3.1 | 1.6 | 9.4 |
| KCNR | MUT | 9.2 | 6.1 | 6.1 | 1.8 | 27.5 |
| AMC106c | MUT | 8 | 2.1 | 3.8 | 2.2 | 66.6 |
| SK-N-BE | AMP | 7.8 | 1.8 | 1.8 | 1.4 | 348.9 |
| NMB | AMP | 7.9 | 1.4 | 2.4 | 3.2 | 591.2 |
| SJNB10 | WT | 7.6 | 1.6 | 3.1 | 1.6 | 239.9 |
| SJNB12 | WT | NAb | 1.3 | 3.2 | 0.8 | 268.4 |
| SJNB1 | WT | 8.2 | 1.4 | 2.9 | 0.7 | 282.7 |
| SK-N-AS | WT | 7.2 | 1.4 | 2.3 | 2.6 | 496.8 |
| SJNB6 | WT | NAb | 0.9 | 1.5 | 2.1 | 552.6 |
| SJNB8 | WT | 7.3 | 0.9 | 1.4 | 1.9 | 587.7 |
aALK mRNA from array, average two probesets 208211_s_at and 208212_s_at; bNA, not available.