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Schematic representation of the profile of CD27 and CD127 expression on CD4+ T cells during differentiation into regulatory [forkhead box P3 (FoxP3)+] or effector (FoxP3-) T cells. Patients with CLL exhibit an accelerated pattern of CD27 expression and loss of CD127. Expression of CD27 (blue) and CD127 (red) on T cells through their differentiation in chronic lymphocytic leukaemia (CLL) (dashed line) and control (solid line) patients.
