Fig. 2.

Stimulation and inhibition of tumour necrosis factor (TNF)-α production by macrophages. (a) Immune complex (IC)-mediated stimulation of TNF-α production by macrophages was inhibited by rabbit Fc fragments (Fc). The data represent mean ± standard deviation (s.d.) of duplicate wells from three different experiments. (b) Macrophages were stimulated with opsonized ICs, a cocktail of ICs and erythrocytes (E + ICs) and IC-loaded erythrocytes (lC-E). Negative controls included medium containing human AB+ serum from a healthy donor (medium), rabbit anti-human immunoglobulin (Ig)G and plain erythrocytes (E). The data represent mean ± s.d. of duplicate wells from 63 different individuals.