Figure 1d:

Axial (a–c) maximal intensity projection and (d–f) original subtraction MR images in 37-year-old woman with HER2-positive hormone receptor–negative cancer in left breast. (a, d) Baseline images obtained before NAC show approximately 8-cm lesion with diffuse, nonmasslike enhancement. On (b, e) images obtained during NAC, the tumor is reduced to a small area of faint enhancement, and on (c, f) images obtained after NAC, the tumor is barely visible. Clinical complete response was diagnosed on the basis of MR imaging findings. Final pathologic examination showed pCR.