Table 1.
Genes in the spleen most significantly affected by developmental Pb exposurea
| Name | Gene ID | p-valueb | Ratioc | Direction | Gene Identifier |
|---|---|---|---|---|---|
| Amylase 2, pancreatic | Amy2 | 0.0000220 | 149.14 | Up | BG142417 |
| Pancreatic lipase | Pnlip | 0.0000658 | 8.2 | Up | NM_026925 |
| Carboxypeptidase A2, pancreatic | Cpa2 | 0.0000715 | 41.54 | Up | BE850208 |
| Chymotrypsin C (caldecrin) | Ctrc | 0.0000829 | 31.72 | Up | NM_007919 |
| Carboxypeptidase A1 | Cpa1 | 0.0001760 | 167.2 | Up | BC052661 |
| Trypsin 4 | Try4 | 0.0006028 | 47.58 | Up | AI386046 |
| Chymotrypsin C (caldecrin) | Ctrc | 0.0006873 | 48.22 | Up | CF580524 |
| Pellino 2 | Peli2 | 0.0007767 | 3.08 | Up | NM_033602 |
| Vomeronasal 1 receptor, G3 | V1rg3 | 0.0010779 | 7.07 | Up | NM_134204 |
| Indoleamine-pyrrole 2,3 dioxygenase | Indo | 0.0020459 | 3.07 | Up | NM_008324 |
| Amylase 2, pancreatic | Amy2 | 0.0022797 | 21.05 | Up | BM503680 |
| Olfactory receptor 1223 | Olfr1223 | 0.0022916 | 3.28 | Up | NM_146892 |
| Carboxypeptidase B1 (tissue) | Cpb1 | 0.0023351 | 28.91 | Up | AK003061 |
| C-src tyrosine kinase | Csk | 0.0024317 | 3.32 | Up | AK047069 |
| Protease, serine, 3 | Prss3 | 0.0024751 | 5.1 | Up | CF580442 |
| Calcineurin binding protein 1 | Cabin1 | 0.0036986 | 3.93 | Up | BY571589 |
| Ring finger protein 138 | Rnf138 | 0.0040949 | 3.88 | Up | NM_019706 |
| Olfactory receptor 1225 | Olfr1225 | 0.0047093 | 3.72 | Up | NM_146891 |
| CUB and zona pellucida-like domains 1 | Cuzd1 | 0.0052438 | 3.85 | Up | NM_008411 |
| Cytochrome P450, family 3, subfamily a, polypeptide 44 | Cyp3a44 | 0.0059048 | 3.79 | Up | NM_177380 |
| Protocadherin 9 | Pcdh9 | 0.0065029 | 3.36 | Up | BB188861 |
| Histone cluster 1, H2aa | Hist1h2aa | 0.0067366 | 3.59 | Down | NM_175658 |
| Ribonuclease, RNase A family, 1 (pancreatic) | Rnase1 | 0.0080881 | 4.05 | Up | NM_011271 |
| Carboxyl ester lipase | Cel | 0.0080991 | 6.68 | Up | NM_009885 |
| Olfactory receptor 643 | Olfr643 | 0.0092722 | 4.34 | Up | NM_147077 |
| N-myc downstream regulated gene 1 | Ndrg1 | 0.0092926 | 5.14 | Up | NM_008681 |
| Kyphoscoliosis peptidase | Ky | 0.0095591 | 3.27 | Up | NM_024291 |
| Tight junction protein 3 | Tjp3 | 0.0100910 | 3.83 | Up | NM_013769 |
a
Pair-wise comparison of mouse spleen codelink data from 3 control litters and 3 Pb-exposed litters.
b
Student’s t-test, significant for P ≤ 0.05.
c
Ratio = Pb signal/control signal when direction is Up, and control signal/Pb signal when direction is Down.