Table 3.

Effect of developmental Pb exposure on genes in the spleen associated with apoptosis^a

Gene Name	Gene ID	p-valueb	Ratioc	Direction	Gene Identifier
B-cell leukemia/lymphoma 2	Bcl2	0.00237	1.39	Down	NM_009741
Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)	Pik3r3	0.00533	1.56	Up	NM_181585
Caspase 12	Casp12	0.01226	2.12	Up	NM_009808
B-cell leukemia/lymphoma 10	Bcl10	0.01252	1.69	Up	NM_009740
Tnf receptor-associated factor 2	Traf2	0.01697	5.89	Up	NM_009422
Thymoma viral proto-oncogene 1	Akt1	0.01752	1.28	Down	NM_009652
Baculoviral IAP repeat-containing 2	Birc2	0.02239	2.07	Up	NM_007465
RIKEN cDNA 1500003O03 gene	1500003O03Rik	0.02432	2.24	Up	NM_019769
Colony stimulating factor 2 receptor, beta 1,	Csf2rb1	0.02465	2.86	Up	BY529130
CASP8 and FADD-like apoptosis regulator	Cflar	0.02502	2.11	Up	BC023121
Baculoviral IAP repeat-containing 3	Birc3	0.02803	2.4	Up	NM_007464
Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	Pik3r1	0.02956	1.76	Up	AW824975
Fas (TNFRSF6)-associated via death domain	Fadd	0.03329	2.25	Up	NM_010175
Protein kinase, cAMP dependent, catalytic, alpha	Prkaca	0.03852	1.46	Up	BI991369
Protein kinase, cAMP dependent regulatory, type II beta	Prkar2b	0.03992	2.75	Up	NM_011158
tumor necrosis factor (ligand) superfamily, member 10	Trail	0.04009	2.39	Up	NM_009425
Caspase 7	Casp7	0.04100	1.5	Up	NM_007611
Apoptotic peptidase activating factor 1	Apaf1	0.04378	3.08	Up	NM_009684
Caspase 6	Casp6	0.04481	2.84	Down	NM_009811
V-rel reticuloendotheliosis viral oncogene homolog A (avian)	Rela	0.04625	1.78	Down	BY184365

^aMouse spleen data from 3 control and 3 Pb-exposed whole mouse genome microarrays.

Results were analyzed by pair-wise comparison using GeneSifter software.

^bSignificance was determined by Student’s t-test, p≤0.05.

^cRatio=Pb signal/control signal when the direction is Up, and control signal/Pb signal when the direction is Down