Table 4.

Effect of developmental Pb exposure on B-cell associated genes in the spleen^a

Gene Name	Gene ID	p-valueb	Ratioc	Direction	Gene Identifier
Recombination activating gene 2	Rag2	0.00207	1.83	Up	NM_009020
Interleukin 7	Il7	0.01355	3.42	Up	NM_008371
Leukocyte immunoglobulin-like receptor, subfamily B	Lilrb3	0.01695	1.54	Up	NM_008848
B-cell leukemia/lymphoma 6	Bcl6	0.01800	2.58	Up	BE985970
B and T lymphocyte associated	Btla	0.01864	2.58	Up	NM_177584
RNA binding motif protein 24	Rbm24	0.02275	2.35	Up	BM943034
Immunoglobulin heavy chain 6 (heavy chain of IgM)	Igh-6	0.02972	3.63	Up	X56392
CD antigen 27	Cd27	0.03047	1.96	Up	L24495
Nonhomologous end-joining factor 1	Nhej1	0.03146	2.45	Down	NM_010544
Histone deacetylase 9	Hdac9	0.03271	1.81	Up	AF324492
Histocompatibility 2, class II antigen A, beta 1	H2-Ab1	0.03447	2.65	Up	NM_207105
Notch gene homolog 2 (Drosophila)	Notch2	0.03941	2.25	Up	NM_010928
Interleukin 4	Il4	0.04138	2.24	Up	NM_021283
Protein kinase, DNA activated, catalytic polypeptide	Prkdc	0.04352	1.44	Up	NM_011159
Tumor necrosis factor (ligand) superfamily, member 13b	Tnfsf13b	0.04670	1.67	Up	NM_033622
Histone deacetylase 7A	Hdac7a	0.04715	2.71	Up	NM_019572
Interleukin 7 receptor	Il7r	0.04741	1.87	Up	NM_008372
Interleukin 21	Il21	0.04863	2.09	Up	NM_021782

^aMouse spleen data from 3 control and 3 Pb-exposed whole mouse genome microarrays.

Results were analyzed by pairwise comparison using GeneSifter software.

^bSignificance was determined by Student’s t-test, p≤0.05.

^cRatio=Pb signal/control signal when the direction is Up, and control signal/Pb signal when the direction is Down