Table 5.

List of cytokines in the spleen affected by Pb exposure^a

Gene Name	Gene ID	p-valueb	Ratioc	Direction	Gene Identifier
Interferon alpha 1	Ifna1	0.0094344	1.33	Down	NM_010502
Inhibin beta-A	Inhba	0.0129858	2.01	Up	NM_008380
Interleukin 7	Il7	0.0135505	3.42	Up	NM_008371
Interleukin 20	Il20	0.0193603	1.66	Up	NM_021380
Bone morphogenetic protein 8a	Bmp8a	0.0222596	3.35	Down	NM_022033
Interleukin 5	Il5	0.0231758	1.99	Up	NM_010558
Oncostatin M	Osm	0.0293897	1.52	Up	AK087945
Interleukin 4	Il4	0.0413793	2.24	Up	NM_021283
Interleukin 31	Il31	0.0451831	2.15	Up	AK005939
Interleukin 21	Il21	0.0486276	2.09	Up	NM_021782

^aMouse spleen data from 3 control and 3 Pb-exposed whole mouse genome microarrays.

Results were analyzed by pair-wise comparison using GeneSifter software.

^bSignificance was determined by Student’s t-test, p≤0.05.

^cRatio=Pb signal/control signal when the direction is Up, and control signal/Pb signal when the direction is Down