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. 2011 Nov 13;60(12):3256–3264. doi: 10.2337/db11-0506

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — BOLD activation during the WMT in control and type 1 diabetic (T1DM) subjects during euglycemia and hypoglycemia. Statistical parametric maps of regions of greatest activation during WMTs vs. control tasks for each subject group and glycemic condition. Functional activations (red-to-yellow color scale) are overlaid on the MNI-152 standard brain anatomy (gray scale). The threshold for activation was P < 0.05 after correction for multiple comparisons using the cluster-based threshold method (see research design and methods). During hypoglycemia, type 1 diabetic subjects exhibit greater activation than control subjects during the WMT. (A high-quality digital representation of this figure is available in the online issue.)