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. 2011 Nov 13;60(12):3256–3264. doi: 10.2337/db11-0506

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 6. — Regions of BOLD activation inversely correlated with HbA_1c in patients with type 1 diabetes. Upper: Statistical parametric map of the correlation of WMT activation with HbA_1c in patients with type 1 diabetes during hypoglycemia (P < 0.05). Sagittal, coronal, and axial slices (from left to right) showing activation correlation in a red-to-yellow scale overlaid on the MNI-152 standard brain anatomy (gray scale). These HbA_1c-correlated activation clusters were identified in the right parahippocampal gyrus and amygdala using the Harvard-Oxford Cortical Structural Atlas. Lower: Plots of regional percent BOLD activation vs. HbA_1c for patients with type 1 diabetes during euglycemia (left) and hypoglycemia (right). Filled circles with error bars: average percent BOLD activation for each patient ± SD within the region of activation. The line is the linear regression best fit of the data with its correlation coefficient R². (A high-quality digital representation of this figure is available in the online issue.)