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. 2011 Nov 13;60(12):3197–3207. doi: 10.2337/db11-0232

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Wld^S protein is highly expressed in pancreatic β-cells and has no effect on the morphology of islets. A: Wld^S protein levels of the indicated tissues were determined by Western blot. Tubulin was used as a loading control. WAT, white adipose tissue; BAT, brown adipose tissue. B: Quantification of Wld^S protein levels in A. Except where indicated, in this and all other figures, error bars represent SD. C: The expression of Wld^S in frozen pancreatic sections of the indicated genotypes was measured by immunofluorescence using antibodies against Wld^S and insulin. DAPI was used to visualize the nuclei. Scale bar, 20 μm. D: Hematoxylin and eosin staining of the pancreatic sections. Scale bar, 40 μm. E and F: Percentage of islet area (E) and islet cell density (F) in 16-week-old Wld^S mice were similar to wild-type (WT) mice (n = 4 for each genotype). (A high-quality digital representation of this figure is available in the online issue.)