FIG. 1.

Hepatic glucose production is not crucial for the control of fasting glycemia. G6Pase activities (A) and glycogen content (B) were assayed in the liver of L-G6pc^−/− (black bar) and WT (white bar) mice in the fed state (0 h) or in fasted states (6 h, 24 h, and 40 h; n = 5 to 6 mice per group). C: Blood glucose concentrations were determined afterward for 0, 6, 16, 24, 30, 40, and 45 h fasting in L-g6pc^−/− and WT mice. D: EGP was determined in conscious L-G6pc^−/− (black bar) and WT (white bar) mice fasted for 6 h or 24 h (n = 6 mice per group). Mice had free access to water during fasting. Data were obtained 5 weeks after gene deletion and are expressed as means ± SEM. Values significantly different from WT (**P < 0.01). ††, significantly different with respect to the value in fed state in each group (P < 0.01). Φ and ΦΦ, significantly different with respect to the value at 6 h of fasting in each group (P < 0.05 and P < 0.01, respectively).