FIG. 1.

Mice lacking β-cell ABCA1 show impaired glucose tolerance, impaired insulin secretion, impaired islet cholesterol efflux, and increased islet cholesterol levels. A: Plasma glucose levels during glucose tolerance test (n = 5). B: Glucose-stimulated insulin secretion from isolated islets. Values represent pooled data from three separate experiments; each consisted of pooled islets from three mice per genotype, and values are expressed as percent of islet content relative to basal secretion, which is arbitrarily set to 1. C: Cholesterol efflux toward apoA1. Values represent pooled data from three separate experiments. D: Islet cholesterol levels (n = 4). ***P < 0.001 compared with controls.