FIG. 5.

Major alterations to Golgi organization in ABCA1^−P/−P β-cells. The Golgi region in β-cells from control mice (A and B) reflected the hallmark architecture of Golgi membranes organized as a series of “compact regions” of stacked cisternae connected laterally to form a ribbon. Golgi region in β-cells from ABCA1^−P/−P mice (C and D) demonstrated a tendency toward circular organization with more ordered and tightly stacked appearance, both at the level of increased cisternal stacking and increased lateral continuity along the length of the ribbon itself. GA, Golgi apparatus; M, mitochondrion; N, nucleus. Bars, 1 μm (except for inset, 500 nm).