Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
GLP-1 downregulates SirT1 expression. A and B: Cells (A) and isolated rat islets (B) were incubated in serum-free medium in the absence or presence of GLP-1 or left untreated in complete growth medium for 24 h. SirT1 expression levels were measured by quantitative PCR and normalized to actin. C: SirT1 protein levels were evaluated by Western blot in INS cells treated as described in A and B. D: Densitometry analysis of three different experiments as shown in A and B. *P < 0.05.
