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Tissue-specific glucose uptake in the basal state or hyperinsulinemic-euglycemic state in mice with diet-induced obesity. Throughout the experiment, mice received intracerebroventricular infusion of vehicle (□ and ■) or tolbutamide (▨). A: Brain. B: Heart. C: Muscle. D: Epigonadal fat. E: Subcutaneous fat. F: Visceral fat. Values represent means ± SEM for at least seven mice per group. *P < 0.05, basal vs. hyperinsulinemic state.
