TABLE 2.

Plasma parameters of mice with diet-induced obesity, in a basal or hyperinsulinemic-euglycemic state, as measured at the end of the experiments

	Basal state: vehicle	Hyperinsulinemic-euglycemic state
		Vehicle	Tolbutamide
Body weight (g)	36.4 ± 0.8	37.6 ± 1.5	37.4 ± 0.7
Glucose (mmol/L)	5.1 ± 0.4	5.8 ± 0.4	6.2 ± 0.3
FFA (mmol/L)	0.7 ± 0.1	0.3 ± 0.1*	0.3 ± 0.1*
Insulin (ng/mL)	1.4 ± 0.4	7.5 ± 0.5*	7.9 ± 0.6*
Hematocrit (%)	44.3 ± 0.6	42.2 ± 1.0	42.4 ± 0.8

Data are means ± SEM for at least six mice per group. Throughout the experiments, mice received intracerebroventricular infusion of vehicle or tolbutamide.

*P < 0.01 basal vs. hyperinsulinemic state.