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. 2011 Nov 13;60(12):3110–3120. doi: 10.2337/db11-0061

FIG. 4.

FIG. 4.

Involvement of Mlx in the glucose repression of Gck. Hepatocytes were either untreated (open bars) or treated with vectors for expression of Mlx-DN or Mlx-WT. After 18-h preculture they were incubated for 4 h at either 5 mmol/L glucose (5) or 25 mmol/L glucose + 2 μmol/L S4048 [(25)S]. A: mRNA levels expressed relative to untreated cells at 25 mmol/L glucose + 2 μmol/L S4048. Means ± SEM, n = 4. *P < 0.05, **P < 0.01, effect of Mlx-DN; #P < 0.05, effect of Mlx-WT. B: Fractional contribution of Mlx to glucose-regulated gene expression calculated from the Mlx-DN attenuation relative to the glucose response calculated from the data in A.