Table 1.

Summary results for efficacy of paracetamol/codeine combinations from randomised, double-blind, placebo-controlled trials in acute pain

		At least 50% pain relief		At least 50% pain
		with paracetamol and		relief with placebo
		codeine
Paracetamol +	Number of	Number	Percent	Number	Percent	Relative benefit	NNT (95% CI)
codeine dose	trials	/total	(95%CI)	/total	(95%CI)	(95% CI)
1000 mg + 60 mg	3	65/114	57 (48-66)	9/83	11(4-18)	4.8 (2.6 to 8.8)	2.2 (1.7 to 2.9)
600/650 mg + 60 mg	13	191/398	48 (43-53)	78/418	19 (15-22)	2.5 (2.0 to 3.1)	3.4 (2.8 to 4.3)
300 mg + 30 mg	4	56/215	26 (20-32)	14/164	9 (4-13)	3.2 (1.8 to 5.6)	5.6 (4.0 to 9.8)

For inclusion there had to be at least two studies.