Table 2.
Comparison of metformin-associated lactic acidosis and very severe lactic acidosis of other origin (pH < 7.0)
| All patients with pH < 7.0 (n = 41) | MALA (n = 10) | LAOO (n = 31) | |
|---|---|---|---|
| Age, years | 64 ± 13 | 66 ± 9 | 64 ± 14 |
| Male gender | 19 (46%) | 4 (40%) | 15 (48%) |
| SAPS II | 84 ± 18 | 88 ± 23 | 83 ± 16 |
| SOFA score | 14.0 ± 2.9 | 14.3 ± 1.4 | 13.8 ± 3.4 |
| Respiratory | 2.7 ± 1.0 | 2.7 ± 0.9 | 2.8 ± 1.0 |
| Renal | 3.0 ± 1.1 | 4.0 ± 0.0 | 2.6 ± 1.1a |
| Hepatic | 0.5 ± 0.8 | 0.3 ± 0.7 | 0.6 ± 0.9 |
| Cardiovascular | 3.6 ± 1.2 | 4.0 ± 0.0 | 3.4 ± 1.4 |
| Hematologic | 0.8 ± 1.1 | 0.5 ± 0.8 | 0.9 ± 1.2 |
| Neurologic | 3.3 ± 1.2 | 2.8 ± 1.5 | 3.5 ± 1.1 |
| Lactate, mmol/L | 18.1 ± 6.5 | 18.7 ± 5.3 | 17.9 ± 6.9 |
| pH | 6.83 ± 0.12 | 6.75 ± 0.13 | 6.86 ± 0.11a |
| Bicarbonate, mmol/L | 9.0 ± 4.8 | 4.4 ± 2.4 | 10.5 ± 4.5a |
| Creatinine, μmol/L | 529 ± 392 | 796 ± 324 | 195 ± 91a |
| Survival | 4 (10%) | 5 (50%) | 0 (0%)a |
Values are presented as mean ± standard deviation or as number (percentage). Comparison with metformin-associated lactic acidosis (MALA): aP < 0.01. LAOO, lactic acidosis of other origin; SAPS II, Simplified Acute Physiology Score II; SOFA, Sequential Organ Failure Assessment.