Table 3.
p38 signaling
| Stimulation | TNF | LPS | MDP | |
|---|---|---|---|---|
| FI (RFU) of pp38 Ly | Healthy subject | 2.5 ± 0.1 | 1.9 ± 0.1 | 1.9 ± 0.1 |
| Patient | 3.4 ± 0.5* | 2.1 ± 0.1 | 2.0 ± 0.1 | |
| % of pp38 positive Ly | Healthy subject | 18.4 ± 2.3 | 3.4 ± 0.3 | 3.4 ± 0.4 |
| Patient | 22.1 ± 2.9 | 4.8 ± 0.6 | 3.2 ± 0.3 | |
| FI (RFU) of pp38 positive Ly | Healthy subject | 6.4 ± 0.3 | 5.5 ± 0.4 | 5.1 ± 0.4 |
| Patient | 7.1 ± 0.6 | 6.6 ± 1.2 | 7.3 ± 1.8 | |
| Stimulation | E. coli | S. aureus | S. epidermidis | |
| FI (RFU) of pp38 Ly | Healthy subject | 2.0 ± 0.1 | 2.1 ± 0.1 | 2.1 ± 0.1 |
| Patient | 2.7 ± 0.2** | 2.9 ± 0.3* | 2.2 ± 0.1 | |
| % of pp38 positive Ly | Healthy subject | 8.3 ± 0.9 | 6.1 ± 0.6 | 6.9 ± 0.7 |
| Patient | 15.6 ± 1.8** | 16.0 ± 3.5* | 5.4 ± 0.9 | |
| FI (RFU) of pp38 positive Ly | Healthy subject | 6.3 ± 1.0 | 5.2 ± 0.4 | 5.1 ± 0.3 |
| Patient | 6.9 ± 0.7 | 7.5 ± 1.1 | 7.3 ± 1.3 |
FI, fluorescence intensity; LPS, lipopolysaccharide; Ly, lymphocytes; MDP, N-acetylmuralyl-alanyl-D-isoglutamine; TNF-α, tumor necrosis factor-α. N = 9 to 10, *P < 0.05, **P < 0.01 as compared to healthy subject