Table 5.
NFKBIL2 and flanking gene polymorphism genotype frequencies in Kenyan individuals with bacteraemia and controls
| Polymorphism/locationa (major/minor allele) | Status | Genotype distributionb | Genotypic 3 × 2 chi-square (P value) | Heterozygote protection modelc | |||
|---|---|---|---|---|---|---|---|
| AA | Aa | aa | OR (95% CI) | P valued | |||
| rs10448143, -5,224, 5' upstream (C/T) | Control | 433 (89.6%) | 50 (10.4%) | 0 (0%) | 0.250e | 0.78 (0.52 to 1.17) | 0.226 |
| Bacteraemia | 598 (91.4%) | 54 (8.3%) | 2 (0.3%) | ||||
| rs2170096, -4,368, 5' upstream (C/G) | Control | 128 (38.7%) | 136 (41.1%) | 67 (20.2%) | 0.145 | 0.93 (0.66 to 1.31) | 0.672 |
| Bacteraemia | 107 (45.7%) | 92 (39.3%) | 35 (15.0%) | ||||
| rs4925858, -3,771, 5' upstream (G/A) | Control | 255 (46.4%) | 247 (44.9%) | 48 (8.7%) | 0.128 | 0.80 (0.64 to 1.00) | 0.053 |
| Bacteraemia | 343 (49.9%) | 271 (39.4%) | 73 (10.6%) | ||||
| rs760477, -263, NFKBIL2 intron 4 (C/T) | Control | 262 (53.0%) | 192 (38.9%) | 40 (8.1%) | 0.009 | 0.68 (0.53 to 0.87) | 0.002 |
| Bacteraemia | 403 (60.6%) | 201 (30.2%) | 61 (9.2%) | ||||
| rs2306384, +2,754, Ser/Gly, NFKBIL2 exon 11 (A/G) | Control | 238 (45.0%) | 224 (42.3%) | 67 (12.7%) | 0.427 | 0.84 (0.65 to 1.09) | 0.195 |
| Bacteraemia | 214 (47.9%) | 171 (38.3%) | 62 (13.8%) | ||||
| rs4082353, +12,589, NFKBIL2 intron 25 (G/T) | Control | 160 (47.6%) | 132 (39.3%) | 44 (13.1%) | 0.857 | 1.05 (0.75 to 1.47) | 0.785 |
| Bacteraemia | 109 (45.4%) | 97 (40.4%) | 34 (14.2%) | ||||
| rs2272658, +16,899, VPS28 intron 4 (C/T) | Control | 135 (40.9%) | 145 (43.9%) | 50 (15.2%) | 0.927 | 0.96 (0.69 to 1.33) | 0.791 |
| Bacteraemia | 113 (42.5%) | 114 (42.9%) | 39 (14.7%) | ||||
| rs13258200, +36,964, CPSF1 intron 2 (A/C) | Control | 212 (37.7%) | 245 (43.6%) | 105 (18.7%) | 0.801 | 1.06 (0.85 to 1.33) | 0.601 |
| Bacteraemia | 259 (37.5%) | 311 (45.1%) | 120 (17.4%) | ||||
| rs4380978, +68,695, ADCK5 intron 1 (G/C) | Control | 246 (45.6%) | 231 (42.8%) | 63 (11.6%) | 0.648 | 0.90 (0.71 to 1.13) | 0.352 |
| Bacteraemia | 329 (47.7%) | 277 (40.1%) | 84 (12.2%) | ||||
VPS28, vacuolar protein sorting 28; CPSF1, cleavage and polyadenylation-specific factor 1; ADCK5, aarF domain-containing kinase 5; OR, odds ratio; CI, confidence interval; IPD, invasive pneumococcal disease. aSNP positions listed are relative to the start of translation (in exon 5). bNumber of individuals (%). cComparison of heterozygotes [Aa] with homozygotes [AA + aa]. d2 × 2 chi-squared comparison, one degree of freedom. eFisher's exact test (two-tailed). P values below 0.05 are highlighted in bold.