Table 1.
Clinical patients' characteristics
| Parameters | Overall population n = 105 |
Septic n = 37 (35%) |
Non-septic n = 68 (65%) |
P value |
|---|---|---|---|---|
| Age, years | 38.1 ± 16.9 | 34.8 ± 15.6 | 39.9 ± 17.5 | 0.15a |
| Male, % (n) | 72.4% (n = 76) | 78.4% (n = 29) | 69.1% (n = 47) | 0.43b |
| ISS | 37.1 ± 9.9 | 38.7 ± 8.9 | 36.2 ± 10.4 | 0.20a |
| Severe brain injury, % (n) | 41% (n = 43) | 59% (n = 22) | 31% (n = 21) | 0.008b |
| Severe thoracic injury, % (n) | 72% (n = 76) | 65% (n = 24) | 76% (n = 52) | 0.30b |
| SAPS II | 36.9 ± 15.6 | 43 ± 15.4 | 33.5 ± 14.8 | 0.003a |
| Delay for MAP >65 mm Hg, minutes | 0 (0 to 0.25) | 0 (0 to 16.25) | 0 (0 to 0) | 0.14c |
| Need for vasoactive support in emergency room, % (n) | 24% (n = 25) | 35% (n = 13) | 18% (n = 12) | 0.077b |
| Prophylactic antibiotics administrated in emergency room, % (n) | 42% (n = 44) | 35% (n = 13) | 46% (n = 31) | 0.41b |
| SOFA score | ||||
| D1 | 4 (2 to 7) | 6 (4 to 9.2) | 3 (2 to 5) | 0.0001c |
| D2 | 4 (2 to 6) | 6 (3.75 to 9.25) | 2.5 (1 to 5) | <0.0001c |
| D3 | 3 (1 to 5) | 7 (3 to 9.25) | 2 (1 to 3) | <0.0001c |
| D4 | 2 (1 to 5) | 5 (2 to 8) | 2 (1 to 3) | <0.0001c |
| D5 | 2 (1 to 4) | 4 (1.75 to 7.25) | 1 (1 to 2) | <0.0001c |
| D6 | 1 (1 to 3) | 3 (1 to 7) | 1 (1 to 2) | <0.0001c |
| mHLA-DR levels, antibodies per cell | ||||
| D1 and 2 | 11,371 ± 4,870 | 11,753 ± 4,291 | 11,177 ± 5,169 | 0.62a |
| D3 and 4 | 12,224 ± 7,501 | 9,271 ± 6,029 | 13,723 ± 7,766 | 0.004a |
| D5 and 6 | 15,623 ± 9,123 | 11,707 ± 6,004 | 16,602 ± 9535 | 0.05a |
| Variations in mHLA-DR, antibodies per cell | ||||
| D3 and 4/D1 and 2 | 1.25 ± 0.57 | 0.83 ± 0.43 | 1.44 ± 0.53 | <0.0001a |
| D5 and 6/D3 and 4 | 1.37 ± 1.11 | 1.32 ± 0.82 | 1.38 ± 1.18 | 0.83a |
| Deaths at day 28, % (n) | 6% (n = 6) | 8% (n = 3) | 4% (n = 3) | 0.73b |
| Mechanical ventilation, % (n) | 66% (n = 69) | 89% (n = 33) | 53% (n = 36) | 0.0004b |
| Duration of mechanical ventilation, days | 6 (3 to 11) | 9 (6.75 to 19) | 3 (2 to 5.5) | <0.0001c |
| Massive transfusion required, % (n) | 29% (n = 31) | 35% (n = 13) | 26% (n = 18) | 0.48b |
| Volume of transfusion, mL | 900 (0 to 2,850) | 1,200 (0 to 3,500) | 0 (0 to 2,700) | 0.067c |
| Shock (need for vasoactive drug on D1 and 2), % (n) | 33% (n = 35) | 57% (n = 21) | 21% (n = 14) | 0.0004b |
| Length of stay in ICU, days | 9 (6 to 15) | 15 (10 to 24.25) | 7 (5 to 11) | <0.0001c |
Parametric variables are expressed as mean ± standard deviation, and non-parametric variables are expressed as median (interquartile range) or frequencies. aIndependent samples t test; bchi-square test; cMann-Whitney test. D, days; ICU, intensive care unit; ISS, Injury Severity Score; MAP, mean arterial pressure; mHLA-DR, monocyte human leukocyte antigen-DR; SAPS II, Simple Acute Physiology Score II; SOFA, Sepsis-related Organ Failure Assessment.