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. Author manuscript; available in PMC: 2012 Nov 8.
Published in final edited form as: Biochemistry. 2011 Oct 17;50(44):9424–9433. doi: 10.1021/bi201157t

Figure 6. Comparison of metal binding by a standard G•U and a reverse G•U wobble.

Figure 6

Standard G•U wobble base pairs (left) are often associated with major groove Mg(H2O)62+ binding sites (PDBID 1HR2). G25 and U20 base pair in the reverse G•U wobble geometry (right). This helps to create a binding site for a largely hydrated Mg2+ ion in the minor groove. The minor groove is on the left in both panels.