Figure 1. In vivo activity of compound 3 in the mouse model.

Balb/C mice were infected intranasally with ∼10³ M. tuberculosis H37Rv. Drug treatment was initiated 1 week after infection and was administered orally for 28 days daily at 25 mg kg⁻¹ (red circles) and 100 mg kg⁻¹ (blue diamonds). Bacterial loads were determined after 14 and 28 days of drug treatment and compared with the control group (HPβCD formulation alone, black squares). Isoniazid (green triangles, 25 mg kg⁻¹) was used as a positive control.