Fig. 1.

Left panel: the median concentration of follicular fluid soluble HLA-G was 35.5 U/mL (6.1, 118.2) in normal fertilization group and 173.3 U/mL (55.1, 187.8) in fertilization failure group (p=0.140, Wilcoxon test). Right panel: ROC curve analysis showed that high level of sHLA-G (>117.758 U/mL) could predict the failure of fertilization with a statistical significance (AUC 0.676, 95% CI 0.525-0.804, sensitivity 71.4%, specificity 75.6%, positive LR 2.93, negative LR 0.38). HLA-G, human leukocyte antigen G; ROC, receiver operating characteristic; AUC, area under curve; CI, confidence interval; LR, likelihood ratio.