Fig. 1.

Schematic overview of Th1-associated chemokines and their receptors. Representative Th1-associated chemokine receptors are CXCR3 and CCR5. (A) CXCR3 is a receptor for CXCL9, CXCL10 and CXCL11, and is known to be expressed in Th1 CD4⁺ T cells and CD8⁺ T cells, especially in effector and effector memory subsets. (B) CCR5 is a receptor for CCL3, CCL4 and CCL5, though CCL3 and CCL5 bind to other receptors redundantly. CCR5 is also expressed in effector and effector memory subsets of Th1 CD4⁺ T cells and CD8⁺ T cells. MIG, monokine induced by interferon-γ; IP-10, interferon-γ-inducible protein-10; I-TAC, interferon-inducible T-cell α chemoattractant; MIP-1α, macrophage inflammatory protein-1α; MIP-1β, macrophage inflammatory protein-1β; RANTES, regulated on activation normal T cell expressed and secreted; Th1, T helper 1.