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Conjugation of pepstatin A to cystatin C T102C through a solubilizing peptide carrying a C-terminal MTS-cysteine residue. Conditions: (i) EDC/HOSu in DMF 96% yield; (ii) Fmoc-lysine/DMF, 89% yield; (iii) Fmoc-based solid phase peptide synthesis; (iv) PBS with 6% v/v DMSO, >90% conversion, 95% protein recovery.
