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. 2011 Jul 28;111(5):1467–1476. doi: 10.1152/japplphysiol.00539.2011

Fig. 3.

Fig. 3.

Cleaved caspase-3 (A) and its downstream substrate poly(ADP-ribose) polymerase-1 (PARP-1; B and D) in whole lung homogenates of mice subjected to control (lane 1), LIC (lane 2), and NAC + LIC (lane 3). n = 3 Mice per group. Significantly increased cleavage of caspase-3 and PARP-1 was observed in LIC. NAC + LIC completely inhibited caspase-3 cleavage. Immunofluorescent confocal image of cleaved PARP-1 in control (C), LIC (D), NAC + LIC (E) F: cleaved PARP-1 is increased in LIC compared with control. NAC pretreatment markedly reduced staining for cleaved PARP-1 under the same conditions as LIC. *P < 0.05 compared with control. #P < 0.05 compared with LIC.