Table 2.

Phenotype and serum biochemical profile

	Diet			P Value
	SC (n = 8)	FF (n = 7)	HF (n = 8)	FF vs. HF	FF vs. SC
Body weight, g	28.82 ± 0.48	44.90 ± 1.14	42.83 ± 1.3	0.67	<0.0001*
Liver-to-body weight ratio, %	4.4 + 0.2	8.0 + 0.8	4.2 + 0.3	0.0003*	0.0004*
Serum AST, IU/l	176.9 ± 10.3	488.3 ± 26.8	121 ± 3.0	0.0003*	0.001*
Glucose, mg/dl	168.1 ± 16.3	243.1 ± 25.3	301.0 ± 23.5	0.11	0.03*
Insulin, mU/l	15.10 ± 0.84	37.83 ± 3.9	43.47 ± 3.0	0.67	<0.0001*
HOMA-IR	6.3 ± 0.50	25.5 ± 3.1	34.9 ± 2.8	0.43	<0.0001*
Serum cholesterol, mg/dl	55.1 ± 1.9	298.9 ± 15.4	95.4 ± 4.6	0.0002*	<0.0001*
Total IGF-I, ng/ml	273.1 ± 6.2	435 ± 18.3	353.5 ± 10.6	0.17	0.006*
Growth hormone, ng/ml	21.2 ± 2.1	10.2 ± 1.6	8.7 ± 1.2	0.80	<0.0001*
Adiponectin, ng/ml	15.7 ± 0.64	10.5 ± 0.58	17.8 ± 0.76	0.01*	0.05*

Values are means ± SE.

AST, alanine aminotransferase; HOMA-IR, homeostasis model assessment of insulin resistance; IGF-I, insulin-like growth factor I.

^*Statistical significance.