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. 2011 Jan 11;33(4):565–578. doi: 10.1007/s11357-010-9203-3

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© The Author(s) 2011

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Fig. 3 — Hormone deficiency advances Purkinje cell loss. Mean (± S.E.M) number of Purkinje cells (PC) of intact and gonadectomized (GDX) WT and Rora ^+/sg mice from 3 to 24 months. In WT mice, PC death begins earlier in gonadectomised (GDX) than intact mice. Also GDX removes the sexual dimorphism of PC numbers (Litteria 1994) so that GDX males and females have the same numbers of PCs. In Rora ^+/sg mice in association with their endocrine deficiency there is also no sexual dimorphism in the number of Rora ^+/sg PCs, which have already begun to die by 3 months of age and whose death accelerates from 9 months of age. = range of PC number in males at 1 month (Doulazmi et al. 1999). Significant differences intact vs. GDX: single asterisk P < 0.05. Significant differences WT male vs. female: section sign P < 0.0001

Inline graphic — Hormone deficiency advances Purkinje cell loss. Mean (± S.E.M) number of Purkinje cells (PC) of intact and gonadectomized (GDX) WT and Rora ^+/sg mice from 3 to 24 months. In WT mice, PC death begins earlier in gonadectomised (GDX) than intact mice. Also GDX removes the sexual dimorphism of PC numbers (Litteria 1994) so that GDX males and females have the same numbers of PCs. In Rora ^+/sg mice in association with their endocrine deficiency there is also no sexual dimorphism in the number of Rora ^+/sg PCs, which have already begun to die by 3 months of age and whose death accelerates from 9 months of age. = range of PC number in males at 1 month (Doulazmi et al. 1999). Significant differences intact vs. GDX: single asterisk P < 0.05. Significant differences WT male vs. female: section sign P < 0.0001