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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Behav Pharmacol. 2011 Dec;22(8):785–793. doi: 10.1097/FBP.0b013e32834d13a2

Figure 1.

Figure 1

Effects of morphine, JNJ and MPEP administered systemically on the hotplate (left), warm water tail-withdrawal (center) and capsaicin procedures (right). Morphine was determined on the hotplate and warm water tail-withdrawal procedures using a cumulative dosing procedure, whereas all other tests were conducted using an acute dosing procedure in which drugs were administered 30 mins prior to testing. In the hotplate, warm water tail-withdrawal, and capsaicin procedures, morphine was tested in 16 rats, JNJ in 4–6 rats, and MPEP in 4 rats, respectively. Vertical axis: antinociception expressed as the % of maximal possible effect in the hotplate and warm water tail-withdrawal procedures, and antihyperalgesia expressed as the % of maximal possible effect in the capsaicin procedure. Horizontal axis: dose of morphine, JNJ or MPEP expressed in mg/kg. Vertical bars represent the standard error; where not indicated, the standard error fell within the data point.