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. 2011 Sep 22;286(47):41105–41114. doi: 10.1074/jbc.M111.282467

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Funnel-shaped channel connecting the active-site cavity to solvent in AAO. A, detail showing a bottleneck near the active-site entrance involving Phe-501, Phe-397, and Tyr-92 and the position of conserved His-502 and His-546 (re-side of the flavin ring). B, AAO backbone showing the buried FAD cofactor and the active-site access channel. The figure is based on the AAO crystal structure (Protein Data Bank code 3FIM). The active-site access channel was depicted by CAVER (56). FAD is shown as Corey-Pauling-Koltun (CPK)-colored van der Waals spheres, and amino acids are shown as CPK-colored sticks.