Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Oct 7;286(47):40771–40781. doi: 10.1074/jbc.M111.278374

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 2. — Comparison of the obesity phenotype in Nes-Cre;Mc3r^TB/TB mice and Mc3r^TB/TB mice in chow-fed mice (A–C) and after HFD feeding for 6 weeks (D–F) suggests that actions of MC3R in peripheral tissues impact on obesity. The impact of Mc3r^TB genotype on body weight (BW) (A and D) and FM (B and E) was attenuated by the Nes-Cre transgene in chow-fed conditions (A and B); however, with HFD feeding, this difference was lost (D and E). FFM was not affected by either genotype, irrespective of diet (B and E). Analysis of adiposity (FM as a percentage of body weight) indicated a minimal impact of the Nes-Cre transgene in chow-fed (C) and no impact in HFD-fed (F) conditions. *, p < 0.05 versus Nes-Cre^(+ve) or Nes-Cre^(−ve), n = 5/group. Female mice were used for this study.