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. 2011 Sep 19;286(47):40954–40961. doi: 10.1074/jbc.M111.286906

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Crystallographic interactions between NHE1_CaMBR/Ca²⁺/CaM complexes. A three-dimensional stereo view of the NHE1_CaMBR/Ca²⁺/CaM complex with two symmetry-related neighboring complexes (complex 1 and complex 2) is shown. The crystallographic interaction of the complex with complex 1 is mediated by the C-lobe of CaM, which is tightly attached to the N-terminal helix (α1) of NHE1_CaMBR (arrow). The four CaM EF-hands with bound calcium (orange spheres) are indicated as e1–e4.