Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Sep 13;286(47):41069–41082. doi: 10.1074/jbc.M111.266734

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 6. — Properties of Cl⁻-dependent changes in pH_i in CFTR- and pendrin-transfected FRT cells. A and D, experimental traces showing the effect of forskolin (5 μm) on changes in pH_i following the removal of apical Cl⁻ in CFTR-transfected (A) and pendrin-transfected (D) FRT cell monolayers. Note that untransfected FRT cells produced no response to this maneuver (data not shown). B and E, the effect of fsk and fsk plus GlyH-101 (10 μm) on ΔpH_RA following apical Cl⁻ readdition in CFTR-transfected (B) and pendrin-transfected (E) FRT cells (n = 4; paired observations; *, p < 0.05 compared with apical 0Cl⁻. †, p < 0.01 compared with +forskolin and GlyH-101). C and F, the mean ΔpH_RA produced by the introduction of monovalent (iodide, formate, and chloride) and divalent (oxalate and sulfate) anions following the removal of apical Cl⁻ in CFTR-transfected (C) and pendrin-transfected (F) FRT cells (n = 4; paired observations; *, p < 0.05 compared with Cl⁻ and formate). Error bars, S.E.