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Solution binding dissociation constants KD (μm) between FcγR and IgG
SA, sialylated.
| Immobilization | |||
|---|---|---|---|
| IgG1 |
FcγRI |
||
| Analytes | Affinity | Analytes | Affinity |
| μm | μm | ||
| FcγRI | 0.02 ± 0.009 | IgG1 | 0.0 4 ± 0.02 |
| FcγRIII mutant-1 (171MGKHRY176) | 0.11 ± 0.01 | IgG2 | 2.2 ± 0.3 |
| IgG3 | 0.014 ± 0.008 | ||
| FcγRIII mutant-2 (171MVGKHRY177) | 0.9 ± 0.2 | IgG4 | 0.032 ± 0.018 |
| IgG1-Fc | 0.04 ± 0.014 | ||
| FcγRIII (171LVGSKNV177) | 1.5 ± 0.2 | SA-IgG1-Fc | 0.083 ± 0.006 |
