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Overexpression of MCM3 up-regulates the phosphorylation of Chk1 Ser-345 (A) and Cdk2 Thr-14 (B). Tet-on inducible cells (control, MCM3, and MCM3 T722A) were treated with tetracycline and synchronized at the G1/S phase. Total cell lysates were harvested and subjected to immunoblot with the indicated antibodies.
