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Transmembrane domain substitutions in APP. A, schematic diagram and partial sequences for chimeric molecules based on swAPP. The TMD of APP was removed, and TMDs from other γ-secretase substrates, APLP2, Notch-1, and ErbB4 were inserted. B, sequences of the Aβ-like region of chimeras composed of swAPP with substitutions of short segments from the Notch-1 TMD. Notch-1 sequences are shown in italics.
