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Treatment with Aβ1–42 (250 nm) for 1 or 24 hours (h) increases microglial phagocytic uptake of fluorescent carboxylate-modified microspheres (A). Data are presented as means ± S.E. for ≥3 independent experiments. ***, p < 0.001 versus control. B, microglia plasma membranes were labeled with Alexa Fluor 488-tagged isolectin B4. Scale bars, 10 μm.
