Fig. 6.

Schematic illustration of the AP-2alpha (−654/−55) promoter region (for more detailed information, see Figure 3C) and bisulfite sequencing analysis of its methylation in prostate tumors (T) and normal adjacent tissues (N) taken from five different patients who underwent surgical removal of their prostate for localized prostate cancer. Analysis of tissue samples demonstrated distinct patterns of methylation. Individual CpG dinucleotides in the AP-2alpha promoter region are significantly hypermethylated in prostate tumor tissue in comparison with adjacent normal prostatic tissue. Each line represents an allele; each circle represents a CpG dinucleotide. Filled circles represent methylated CpG dinucleotides and clear circles represent unmethylated CpG dinucleotides.