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. 2011 Nov 18;6(11):e27820. doi: 10.1371/journal.pone.0027820

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Zanin et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Frequency distribution of the cube root of pre-spike foot (PSF) signal duration (A) and spike area (B) illustrates the different ages at which these change. Correlations between PSF signal duration, τ, and spike area, Q (C) shows a linear relationship at all ages (P0: R² = 0.64, p<0.01, 1 month: R² = 0.82, p<0.0001, 6 months: R² = 0.79, p<0.0001). Transforms of this data to ln(1/τ) vs 1/Q^1/3 (D) also provides linear relationships at all ages (P0: R² = 0.81, p<0.0001, 1 month: R² = 0.44, p<0.05, 6 months: R² = 0.59, p<0.01). The slope of this plot, representing membrane curvature [1], increases significantly with age. Green – P0, red – 1 month, blue – 6 months.