Figure 2. Effect of combination of budesonide and formoterol on imiquimod (IQ)-induced markers of innate immunity.

IP-10 (A) and IL-6 (B) production by PBMC from eight healthy female donors were cultured with IQ with budesonide (Bud, 10⁻⁸ M) and/or formoterol (Form,10⁻⁸ M). The background cytokine levels produced in unstimulated control cultures (median 211 pg/ml IP-10 and 238 pg/ml IL-6) have been subtracted. Box and whisker plots show the median and interquartile range with 10^th–90^th percentile. Differences between IQ-stimulated cultures and IQ-stimulated cultures with drugs were tested by Friedman ANOVA and Dunn's multiple comparison test (**, p<0.005; ***, p<0.001).