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. 2011 Nov 18;6(11):e27861. doi: 10.1371/journal.pone.0027861

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Chaykovska et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Gene expression of the marker of left ventricular dysfunction BNP was significantly increased in rats after initiation of uremia. Treatment with linagliptin at a dose of 7 µmol/kg significantly reduced mRNA expression of BNP in uremic rat heart. Values are given in mean ± SEM. N = 7 sham-operated rats, 5 5/6N rats and 12 5/6N linagliptin-treated rats. *p<0.05; ***p<0.001.