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. 2011 Nov 18;6(11):e27861. doi: 10.1371/journal.pone.0027861

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Chaykovska et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Uremic condition led to a significant increase in gene expression of profibrotic factors TGF-β1, TIMP-1, Col1α1 and Col3α1 in the 5/6 nephrectomized rats compared with corresponding sham-operated rats. Linagliptin at a dose of 7 µmol/kg significantly inhibited mRNA expression of profibrotic factors TGF-β1, TIMP-1, Col1α1 and Col3α1 in uremic rat heart. Values are given in mean ± SEM. N = 7 sham-operated rats, 5 5/6N rats, and 12 5/6N linagliptin-treated rats. *p<0.05; ***p<0.001.