Table 1. Characteristics of the model of CRF: kidney function parameters, cardiac histology.

Kidney function parameters	Sham-operated rats	5/6 N rats
Endogenous creatinine clearance (ml/24 h/g BW, mean ± SEM)	4.45±1.5	3.27±0.1***
Cystatin C (ng/ml, mean ± SEM)	700±35.7	1434±77.6***
β2-microglobulin (µg/ml, mean ± SEM)	20.4±2.4	33.3±1.34***
NGAL (ng/ml, mean ± SEM)	286±23	680±56.3***
Osteopontin (ng/ml, mean ± SEM)	33.5±3.2	56.1±6.2***
Relative left ventricular weight (left ventricular weight/body weight) (%± SEM)Cardiac interstitial fibrosis (% of section ± SEM)Myocyte diameter (µm ± SEM)GLP-1 receptor mRNA in heart tissue	0.20±0.012.1±0.111.8±1.11.12±0.19	0.29±0.03**2.5±0.1*17.1±2.0**0.75±0.15 ***
DPP-4 activity(fluorescence units, mean ± SEM)	84315.77±3844.56	80594.24±3640.53

Values are given in mean±SEM; sham-operated rats group, 5/6N rats, two-tailed students t-test.

*p<0.05;

**p<0.01;

***p<0.001.