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. 2011 Nov 18;6(11):e27861. doi: 10.1371/journal.pone.0027861

Table 1. Characteristics of the model of CRF: kidney function parameters, cardiac histology.

Kidney function parameters Sham-operated rats 5/6 N rats
Endogenous creatinine clearance (ml/24 h/g BW, mean ± SEM) 4.45±1.5 3.27±0.1***
Cystatin C (ng/ml, mean ± SEM) 700±35.7 1434±77.6***
β2-microglobulin (µg/ml, mean ± SEM) 20.4±2.4 33.3±1.34***
NGAL (ng/ml, mean ± SEM) 286±23 680±56.3***
Osteopontin (ng/ml, mean ± SEM) 33.5±3.2 56.1±6.2***
Relative left ventricular weight (left ventricular weight/body weight) (%± SEM)Cardiac interstitial fibrosis (% of section ± SEM)Myocyte diameter (µm ± SEM)GLP-1 receptor mRNA in heart tissue 0.20±0.012.1±0.111.8±1.11.12±0.19 0.29±0.03**2.5±0.1*17.1±2.0**0.75±0.15 ***
DPP-4 activity(fluorescence units, mean ± SEM) 84315.77±3844.56 80594.24±3640.53

Values are given in mean±SEM; sham-operated rats group, 5/6N rats, two-tailed students t-test.

*p<0.05;

**p<0.01;

***p<0.001.