Table 3. AUC of different DPP-4 inhibitors in sham-operated rats vs 5/6N rats.

Treatment	Sham-operated rats, (AUC(0-∞)), nmol•h/lmean±SEM	5/6N rats (AUC(0-∞)), nmol•h/lmean±SEM
Alogliptin 7 µmol/kg	1771±225.5	2445±166.6 *
Linagliptin 0.5 µmol/kg	267.4±28.85	257.5±21.44
Linagliptin 7 µmol/kg	1252±378.8	748.2±74.52
Sitagliptin 7 µmol/kg	3690±103	6238±423 ***

N = 5–6 sham-operated rats and 8–13 5/6N rats.

*p<0.05,

***p<0.001.