Table 3. AUC of different DPP-4 inhibitors in sham-operated rats vs 5/6N rats.
Treatment | Sham-operated rats, (AUC(0-∞)), nmol•h/lmean±SEM | 5/6N rats (AUC(0-∞)), nmol•h/lmean±SEM |
Alogliptin 7 µmol/kg | 1771±225.5 | 2445±166.6 * |
Linagliptin 0.5 µmol/kg | 267.4±28.85 | 257.5±21.44 |
Linagliptin 7 µmol/kg | 1252±378.8 | 748.2±74.52 |
Sitagliptin 7 µmol/kg | 3690±103 | 6238±423 *** |
N = 5–6 sham-operated rats and 8–13 5/6N rats.
*p<0.05,
***p<0.001.